Boc-His(Trt)- Aib-OH

Product Details

Boc-His(Trt)-Aib-OH (protected His-Aib dipeptide) is a protected peptide fragment used in convergent (fragment-condensation) peptide synthesis, which can improve coupling efficiency and reduce racemisation and deletion risk at difficult junctions compared with stepwise assembly. Also known as Boc-histidine(Trt)-alpha-aminoisobutyric acid dipeptide. The trityl (Trt) side-chain group is acid-labile, helps keep the residue soluble during coupling and limits side reactions that affect unprotected side chains. Aib (α-aminoisobutyric acid) promotes helical conformation and resists enzymatic cleavage, a feature of several incretin-type peptides. ApiSyn can supply it alongside related protected derivatives, which simplifies sourcing for multi-residue sequences.